MOTS-c 10MG

MOTS-c (Mitochondrial Transcriptional Upstream Stimulatory Element-Binding Protein-Similar Transcript) is a peptide derived from mitochondrial RNA. Emerging research explores its potential role in mitochondrial function, energy metabolism, and cellular stress responses. This product is provided for academic and professional research purposes only.

Research Context

MOTS-c is a small, non-coding RNA fragment found in mitochondrial transcripts. Initially identified in mice, studies suggest it may influence mitochondrial biogenesis, oxidative stress responses, and metabolic adaptations. Its discovery has sparked interest in its potential as a biomolecular tool for basic research on cellular energetics and stress signaling.

Research Overview

MOTS-c is distinct from traditional coding proteins, as it lacks a traditional open reading frame. However, its sequence contains motifs similar to the transcriptional regulator UPS (Upstream Stimulatory Element-Binding Protein). Early in vivo studies in animal models have observed that MOTS-c expression is upregulated under conditions of metabolic stress, potentially acting as a mitochondrial stress-response regulator. While the precise functional mechanisms remain under investigation, its presence in circulating cell-free RNA has also been documented in mammalian tissues.

Key Research Focus Areas

• Mitochondrial Biogenesis – Investigating whether MOTS-c modulates expression of PGC-1α and other nuclear-encoded transcription factors linked to mitochondrial proliferation.
• Oxidative Stress Response – Exploring its potential role in regulating enzymes involved in reactive oxygen species detoxification, such as catalase or superoxide dismutase.
• Metabolic Adaptation – Evaluating its effects on glucose and lipid metabolism under conditions of fasting or exercise in animal models.
• Cellular Stress Signaling – Assessing whether MOTS-c integrates into pathways involving AMPK, mTOR, or other energy-sensing kinases.
• Circulating Biomarker Potential – Investigating its presence and stability in blood plasma or serum as a research tool for metabolic studies.

Important Research Use Disclaimer

This product is intended solely for use in academic, governmental, or institutional research laboratories. It must not be used for any diagnostic, therapeutic, cosmetic, or human or animal consumption purposes. Research subjects must adhere to all applicable ethical guidelines, regulatory standards, and institutional biosafety protocols. Handling of peptides, including MOTS-c, requires proper sterile techniques and documentation of experimental conditions. Always consult with qualified professionals regarding experimental design, safety procedures, and regulatory compliance.